Biomaterials for the feeder-free culture of human embryonic stem cells and induced pluripotent stem cells

Akon Higuchi, Qing Dong Ling, Yi An Ko, Yung Chang, Akihiro Umezawa

研究成果: 雜誌貢獻回顧評介論文同行評審

91 引文 斯高帕斯(Scopus)

摘要

A scientific review presents biomaterials for the feeder-free culture of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). Tissue-specific stem cell niches provide crucial cell-cell contacts and paracrine signaling. The extracellular matrix ECM) keeps stem cells in the niche and serves to initiate signal transduction, while locally concentrated glycosaminoglycans (GAGs) provide soluble growth factors or cytokines. It will be highly beneficial to design, construct, and reproduce the microenvironment and niche of pluripotent stem cells in vitro with biomacromolecules and synthetic polymers. Culture materials derived from biomacromolecules and synthetic polymers have been used to support the propagation of hESCs and human iPSCs while maintaining their pluripotency.

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頁(從 - 到)3021-3035
頁數15
期刊Chemical Reviews
111
發行號5
DOIs
出版狀態已出版 - 11 5月 2011

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