B- to S-form transition in double-stranded DNA with basepair interactions

Pik Yin Lai, Zicong Zhou

研究成果: 雜誌貢獻會議論文同行評審

7 引文 斯高帕斯(Scopus)


When a DNA in its nature double-helical state is stretched by an external force, its length undergoes a sharp extension from the B-form to the 1.7 times elongated S-form. This phenomenon is investigated in the framework of a model of a double-stranded with basepair interactions and bending. Shape equations governing the structure of the DNA under external forces and torques are derived using a classical mechanical approach. The first-order nature of the B- to S-form transition is revealed clearly in terms of an effective potential with a barrier separating these two states. All the structural properties of the DNA in both forms can be calculated in detail. The configurations of the double strands, relative extension, amount of self-untwisting and the threshold stretching force of the DNA under stretched are obtained and compare well with experimental observations.

頁(從 - 到)170-180
期刊Physica A: Statistical Mechanics and its Applications
出版狀態已出版 - 1 4月 2003
事件Statphys - Taiwan - 2002: Lattice Models and Complex Systems - Taipei and Taichung, Taiwan
持續時間: 26 5月 20021 6月 2002


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