Asymmetric Synthesis of Nabscessin A from Inositol and d -Camphor

Hsin Ying Wu, Wei Yi Wang, Chia Chi Feng, Duen Ren Hou

研究成果: 雜誌貢獻期刊論文同行評審

2 引文 斯高帕斯(Scopus)

摘要

An enantiomer of nabscessin A (1), an aminocyclitol amide with antimicrobial activity, was synthesized from myo-inositol and dimethyl d-camphor acetal in 14 steps. Formal synthesis of natural nabscessin A was also achieved through the new approach to access both enantiomers of 4,5-di-O-benzyl-myo-inositol, derived from the same set of starting materials. This synthesis features utilizations of the existing framework of myo-inositol and a regioselective esterification.

原文???core.languages.en_GB???
頁(從 - 到)13153-13159
頁數7
期刊Journal of Organic Chemistry
85
發行號20
DOIs
出版狀態已出版 - 16 10月 2020

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