Brevipolides are 5,6-dihydro-ã-pyrone derivatives, first reported in 2004 as the inhibitors of the chemokine receptor CCR5 and exhibiting cytotoxicity against cancer cells. Starting from the C2 symmetric diene-diol 2, ent-brevipolide H was synthesized for the first time in 11 steps. The anti-addition of the sulfur ylide to the α,β-unsaturated enones was developed to give the key cyclopropane moiety. The synthetic (-)-brevipolide H showed an IC50 value of 7.7 μM against PC-3 cells. (Chemical Equation Presented).
指紋深入研究「Asymmetric synthesis of (-)-brevipolide H through cyclopropanation of the α,β-unsaturated ketone」主題。共同形成了獨特的指紋。
Kurniawan, Y. D. (貢獻者), Chang, W. (貢獻者), Leu, W. (貢獻者), Chan, S. (貢獻者), Lin, J. (貢獻者) & Hou, D. (貢獻者), The Cambridge Structural Database, 17 10月 2014