Assessment of Polyp and Mass Histopathology by Intravenous Contrast-Enhanced CT Colonography

Ronald M. Summers, Adam Huang, Jianhua Yao, Shannon R. Campbell, Jennifer E. Dempsey, Andrew J. Dwyer, Marek Franaszek, Danny S. Brickman, Ingmar Bitter, Nicholas Petrick, Amy K. Hara

研究成果: 雜誌貢獻期刊論文同行評審

9 引文 斯高帕斯(Scopus)


Rationale and Objectives: We sought to demonstrate that intravenous contrast-enhanced CT colonography (CTC) can distinguish colonic adenomas from carcinomas. Methods: Supine intravenous contrast-enhanced CTC with colonoscopic and/or surgical correlation was performed on 25 patients with colonic adenomas or carcinomas. Standard deviation of mean polyp CT attenuation was computed and assessed using ANOVA and receiver-operating characteristic analyses. Results: Colonoscopy confirmed 32 polyps or masses 1 to 8 cm in size. The standard deviations of CT attenuation were carcinomas (n = 13; 36 ± 6 HU; range 28-48 HU) and adenomas (n = 19; 49 ± 14 HU; range 31-100 HU) (P = 0.005). At a standard deviation threshold of 42 HU, the sensitivity and specificity for classifying a polyp or mass as a carcinoma were 92% and 79%, respectively. The area under the receiver-operating characteristic curve was 0.89 ± 0.06 (95% confidence interval 0.73-0.96). Conclusions: Measurement of the standard deviation of CT attenuation on intravenous contrast-enhanced CTC permits histopathologic classification of polyps 1 cm or larger as carcinomas versus adenomas. The presence of ulceration or absence of muscular invasion in carcinomas creates overlap with adenomas, reducing the specificity of carcinoma classification.

頁(從 - 到)1490-1495
期刊Academic Radiology
出版狀態已出版 - 12月 2006


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