@article{eab0fe6e62824ff9808da45701c842da,
title = "Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia",
abstract = "It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincar{\'e} method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR1-10 was noted only in patients with diabetes. Moreover, a significient correlation between SSR1-10 and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR1-10 after RH in patients with diabetes; and, a significient correlation between SSR1-10 and endothelial function at the moment of RH was noted.",
keywords = "Autonomic dysfunction, Poincar{\'e} method, Pulse rate variability, SD1/SD2 ratio (SSR)",
author = "Wu, {Hsien Tsai} and Hsu, {Po Chun} and Sun, {Cheuk Kwan} and Wang, {Hou Jun} and Liu, {Cyuan Cin} and Chen, {Hong Ruei} and Liu, {An Bang} and Tang, {Chieh Ju} and Lo, {Men Tzung}",
note = "Funding Information: The authors would like to thank the anonymous Reviewers for their insightful comments and suggestions which have significantly contributed to the improvement of this work. The authors also like to thank Miss S. M. Wen, who worked as Acting Head Nurse in the Outpatient Department of Hualien Hospital for clinical Support, the volunteers involved in this study for allowing us to collect and analysis their data. The authors are grateful for the support of Texas Instruments, Taiwan , in sponsoring the low power instrumentation amplifiers and ADC tools. M-T Lo was supported by NSC (Taiwan, ROC) , Grant No 100-2221-E-008-008-MY2 , joint foundation of CGH and NCU , Grant No CNJRF-101CGH-NCU-A4 , VGHUST102-G1-2-3 and NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan ( NSC 101-2911-I-008-001 ). H-T Wu was supported by NSC , Grant No 100-2221-E-259-030-MY2 , NSC 101-2221-E-259-012 . ",
year = "2013",
month = aug,
day = "7",
doi = "10.1016/j.jtbi.2013.03.022",
language = "???core.languages.en_GB???",
volume = "330",
pages = "9--17",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
}
