@article{c59b388e792b4a9992016d12f51c766a,
title = "Assessing vascular endothelial function using frequency and rank order statistics",
abstract = "Using frequency and rank order statistics (FROS), this study analyzed the fluctuations in arterial waveform amplitudes recorded from an air pressure sensing system before and after reactive hyperemia (RH) induction by temporary blood flow occlusion to evaluate the vascular endothelial function of aged and diabetic subjects. The modified probability-weighted distance (PWD) calculated from the FROS was compared with the dilatation index (DI) to evaluate its validity and sensitivity in the assessment of vascular endothelial function. The results showed that the PWD can provide a quantitative determination of the structural changes in the arterial pressure signals associated with regulation of vascular tone and blood pressure by intact vascular endothelium after the application of occlusion stress. Our study suggests that the use of FROS is a reliable noninvasive approach to the assessment of vascular endothelial degeneration in aging and diabetes.",
keywords = "Air pressure sensing system (APSS), Frequency and rank order statistics (FROS), Vascular endothelial function",
author = "Wu, {Hsien Tsai} and Hsu, {Po Chun} and Sun, {Cheuk Kwan} and Liu, {An Bang} and Lin, {Zong Lin} and Tang, {Chieh Ju} and Lo, {Men Tzung}",
note = "Funding Information: We would like to thank the volunteers involved in this study for allowing us to collect and analyze their data. A tribute is also paid to Dr. C. J. Lai of Buddhist Tzu Chi University and Dr. J. H. Yeh of Buddhist Tzu Chi General Hospital for providing professional advice on statistical analysis in this study. This research was partly supported by the National Science Council under Grant NSC100-2221-E-259-030-MY2 , Taiwan, Republic of China. M-T Lo was supported by NSC (Taiwan, ROC) , Grant No 100-2221-E-008-008-MY2 , joint foundation of CGH and NCU , Grant No CNJRF-101CGH-NCU-A4 , VGHUST102-G1-2-3 and NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan ( NSC 101-2911-I-008-001 ).",
year = "2013",
month = aug,
day = "1",
doi = "10.1016/j.physa.2013.03.033",
language = "???core.languages.en_GB???",
volume = "392",
pages = "3122--3131",
journal = "Physica A: Statistical Mechanics and its Applications",
issn = "0378-4371",
number = "15",
}
