Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents

Shao Chun Wang, Yu Shen Hsu, Chia Teng Hsiao, Chang Cheng Wu, Yu Chein Sue, Saad M. Alshehri, Tansir Ahamad, Yusuke Yamauchi, Jeffrey E. Chen, Kevin C.W. Wu, Fa Kuen Shieh

研究成果: 雜誌貢獻期刊論文同行評審

2 引文 斯高帕斯(Scopus)

摘要

We report a series of SBA-15 type mesoporous silica (MS) possessing functional annulated rings of different sizes obtained by post-synthesis grafting with diamines containing backbones and different numbers of carbon atoms as efficient magnetic resonance imaging (MRI) contrasting agents. Interestingly, lanthanide ion adsorption assays in aqueous solutions of pH 7 at room temperature showed that adsorption efficiency was higher for materials with rings than those without rings. Furthermore, annulated MS synthesized with 1,5-diaminopetane exhibited selective chelation with smaller Yb(III) ions owing to the “macrocyclic effect” of the cation cavity that offers a “best fit.” Additionally, Gd(III) ions chelated with the material modified by 1, 5-diaminopetane denoted as Gd@annulated-MS exhibited high r2/r1 relaxivities of 12, 12, and 28 while measured with 7.0 T (300 MHz), 9.4 T (400 MHz), and 11.4 T (500 MHz), respectively. Finally, the nanoscale parent materials for annulated modification were successfully synthesized for further in vivo applications. The MS materials thus obtained open auxiliary avenues for selective lanthanide ion absorption via manipulation of the annular ring size to be potentially applied in new generation MRI contrast agents.

原文???core.languages.en_GB???
頁(從 - 到)165-171
頁數7
期刊Journal of Inorganic and Organometallic Polymers and Materials
26
發行號1
DOIs
出版狀態已出版 - 1 1月 2016

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