Analysis of ultramicro biomedical samples with microfabricated chemical sensors: sample/reagent adsorption on alumina vs. pyrex substrates

Kwong Yue Hui; Richard S. Diefes; Laurie Dudik; Chung Chiun Liu; Miklos Gratzl

Analysis of ultramicro biomedical samples with microfabricated chemical sensors: sample/reagent adsorption on alumina vs. pyrex substrates

Kwong Yue Hui, Richard S. Diefes, Laurie Dudik, Chung Chiun Liu, Miklos Gratzl

材料科學與工程研究所

研究成果: 雜誌貢獻 › 會議論文 › 同行評審

摘要

Microfabricated platinum redox sensors can be used for indication in redox diffusional microtitration of microliter size body fluid samples. The sensor can be deposited onto different substrate materials. Adsorption of reagent and/or sample on alumina ceramic substrate versus Pyrex glass substrate is compared. It is demonstrated that in a classical iodimetric redox titration system, significant adsorption occurs on alumina ceramic substrate, causing irreproducible results. Reproducibility with a 1.7% coefficient of variation (CV) is achieved using a sensor deposited on Pyrex substrate for the analysis of 20 μL sample droplets.

原文	???core.languages.en_GB???
頁（從 - 到）	824-825
頁數	2
期刊	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
卷	16
發行號	pt 2
出版狀態	已出版 - 1994
事件	Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA 持續時間: 3 11月 1994 → 6 11月 1994

引用此

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title = "Analysis of ultramicro biomedical samples with microfabricated chemical sensors: sample/reagent adsorption on alumina vs. pyrex substrates",

abstract = "Microfabricated platinum redox sensors can be used for indication in redox diffusional microtitration of microliter size body fluid samples. The sensor can be deposited onto different substrate materials. Adsorption of reagent and/or sample on alumina ceramic substrate versus Pyrex glass substrate is compared. It is demonstrated that in a classical iodimetric redox titration system, significant adsorption occurs on alumina ceramic substrate, causing irreproducible results. Reproducibility with a 1.7% coefficient of variation (CV) is achieved using a sensor deposited on Pyrex substrate for the analysis of 20 μL sample droplets.",

author = "Hui, {Kwong Yue} and Diefes, {Richard S.} and Laurie Dudik and Liu, {Chung Chiun} and Miklos Gratzl",

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Analysis of ultramicro biomedical samples with microfabricated chemical sensors: sample/reagent adsorption on alumina vs. pyrex substrates. / Hui, Kwong Yue; Diefes, Richard S.; Dudik, Laurie 等.
於: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 卷 16, 編號 pt 2, 1994, p. 824-825.

研究成果: 雜誌貢獻 › 會議論文 › 同行評審

TY - JOUR

T1 - Analysis of ultramicro biomedical samples with microfabricated chemical sensors

T2 - Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2)

AU - Hui, Kwong Yue

AU - Diefes, Richard S.

AU - Dudik, Laurie

AU - Liu, Chung Chiun

AU - Gratzl, Miklos

PY - 1994

Y1 - 1994

N2 - Microfabricated platinum redox sensors can be used for indication in redox diffusional microtitration of microliter size body fluid samples. The sensor can be deposited onto different substrate materials. Adsorption of reagent and/or sample on alumina ceramic substrate versus Pyrex glass substrate is compared. It is demonstrated that in a classical iodimetric redox titration system, significant adsorption occurs on alumina ceramic substrate, causing irreproducible results. Reproducibility with a 1.7% coefficient of variation (CV) is achieved using a sensor deposited on Pyrex substrate for the analysis of 20 μL sample droplets.

AB - Microfabricated platinum redox sensors can be used for indication in redox diffusional microtitration of microliter size body fluid samples. The sensor can be deposited onto different substrate materials. Adsorption of reagent and/or sample on alumina ceramic substrate versus Pyrex glass substrate is compared. It is demonstrated that in a classical iodimetric redox titration system, significant adsorption occurs on alumina ceramic substrate, causing irreproducible results. Reproducibility with a 1.7% coefficient of variation (CV) is achieved using a sensor deposited on Pyrex substrate for the analysis of 20 μL sample droplets.

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M3 - 會議論文

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SN - 0589-1019

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EP - 825

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

IS - pt 2

Y2 - 3 November 1994 through 6 November 1994

ER -

Analysis of ultramicro biomedical samples with microfabricated chemical sensors: sample/reagent adsorption on alumina vs. pyrex substrates

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