Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma

Yen Hung Lin; Lian Yu Lin; Aaron Chen; Xue Ming Wu; Jen Kuang Lee; Ta Chen Su; Vin Cent Wu; Shih Chieh Chueh; Wei Chou Lin; Men Tzung Lo; Pa Chun Wang; Yi Lwun Ho; Kwan Dun Wu

doi:10.1016/j.atherosclerosis.2011.12.003

Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma

Yen Hung Lin, Lian Yu Lin, Aaron Chen, Xue Ming Wu, Jen Kuang Lee, Ta Chen Su, Vin Cent Wu, Shih Chieh Chueh, Wei Chou Lin, Men Tzung Lo, Pa Chun Wang, Yi Lwun Ho, Kwan Dun Wu

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

90 引文斯高帕斯（Scopus）

摘要

Context: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, and is associated with more prominent vascular stiffness and atherosclerosis. However, the effect of adrenalectomy on reversibility of vascular damage is unclear. Objective: Our objective was to investigate the vascular changes and possibility of reversibility after adrenalectomy in PA patients. Methods: We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that received adrenalectomy from October 2006 to December 2008 and 21 patients with essential hypertension (EH) were enrolled as the control group. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound of the right common carotid arteries and pulse wave velocity (PWV) measurement including brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV) were performed in both groups. The follow-up measurements were performed one-year after adrenalectomy in APA group. Results: APA patients had significantly higher diastolic blood pressure, plasma aldosterone concentration (PAC) and aldosterone-renin ratio (ARR), but lower serum potassium level and plasma renin activity (PRA) than EH patients. APA patients had significantly higher CIMT (0.64 ± 0.13 vs. 0.53 ± 0.10. mm, p= 0.006), higher baPWV (1589 ± 296 vs. 1405 ± 187. cm/s, p= 0.024) and haPWV (1095 ± 150 vs. 987 ± 114. cm/s, p= 0.013) comparing with EH patients. One-year after adrenalectomy, CIMT reduced significantly from 0.64 ± 0.13. mm to 0.59 ± 0.14. mm (p= 0.014), and baPWV and haPWV also showed significant reduction (baPWV, 1589 ± 296 to 1463 ± 188. cm/s, p= 0.035; haPWV, 1095 ± 150 to 1017 ± 109. cm/s, p= 0.019). Conclusion: APA patients have higher degree of early atherosclerosis and vascular stiffness. Adrenalectomy not only corrects the high blood pressure and biochemical parameters but also reverse adverse vascular change in APA patients.

原文	???core.languages.en_GB???
頁（從 - 到）	154-159
頁數	6
期刊	Atherosclerosis
卷	221
發行號	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2011.12.003
出版狀態	已出版 - 3月 2012

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10.1016/j.atherosclerosis.2011.12.003

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Lin, Y. H., Lin, L. Y., Chen, A., Wu, X. M., Lee, J. K., Su, T. C., Wu, V. C., Chueh, S. C., Lin, W. C., Lo, M. T., Wang, P. C., Ho, Y. L., & Wu, K. D. (2012). Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma. Atherosclerosis, 221(1), 154-159. https://doi.org/10.1016/j.atherosclerosis.2011.12.003

@article{754b51b651e449d5ad46e9869dc8c466,

title = "Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma",

abstract = "Context: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, and is associated with more prominent vascular stiffness and atherosclerosis. However, the effect of adrenalectomy on reversibility of vascular damage is unclear. Objective: Our objective was to investigate the vascular changes and possibility of reversibility after adrenalectomy in PA patients. Methods: We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that received adrenalectomy from October 2006 to December 2008 and 21 patients with essential hypertension (EH) were enrolled as the control group. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound of the right common carotid arteries and pulse wave velocity (PWV) measurement including brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV) were performed in both groups. The follow-up measurements were performed one-year after adrenalectomy in APA group. Results: APA patients had significantly higher diastolic blood pressure, plasma aldosterone concentration (PAC) and aldosterone-renin ratio (ARR), but lower serum potassium level and plasma renin activity (PRA) than EH patients. APA patients had significantly higher CIMT (0.64 ± 0.13 vs. 0.53 ± 0.10. mm, p= 0.006), higher baPWV (1589 ± 296 vs. 1405 ± 187. cm/s, p= 0.024) and haPWV (1095 ± 150 vs. 987 ± 114. cm/s, p= 0.013) comparing with EH patients. One-year after adrenalectomy, CIMT reduced significantly from 0.64 ± 0.13. mm to 0.59 ± 0.14. mm (p= 0.014), and baPWV and haPWV also showed significant reduction (baPWV, 1589 ± 296 to 1463 ± 188. cm/s, p= 0.035; haPWV, 1095 ± 150 to 1017 ± 109. cm/s, p= 0.019). Conclusion: APA patients have higher degree of early atherosclerosis and vascular stiffness. Adrenalectomy not only corrects the high blood pressure and biochemical parameters but also reverse adverse vascular change in APA patients.",

keywords = "Adrenalectomy, Aldosterone producing adenoma, Carotid intima media thickness, Primary aldosteronism, Pulse wave velocity",

author = "Lin, {Yen Hung} and Lin, {Lian Yu} and Aaron Chen and Wu, {Xue Ming} and Lee, {Jen Kuang} and Su, {Ta Chen} and Wu, {Vin Cent} and Chueh, {Shih Chieh} and Lin, {Wei Chou} and Lo, {Men Tzung} and Wang, {Pa Chun} and Ho, {Yi Lwun} and Wu, {Kwan Dun}",

note = "Funding Information: This study was supported by Ta-Tung Kidney Foundation, National Taiwan University Hospital ( NTUH 99-M1427 ), Department of Health, Executive Yuan, R.O.C. (Grant DOH 99-TD-B-111-001 ), Taiwan National Science Council (Grants NSC 97-2314-B-002-155-MY2 and NSC 100-2314-B-002-139 ), and Taiwan National Science Council support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan ( NSC 99-2911-I-008-100 ). We thank Ms. Hsien Fen-Fun for medical technologic support and the staff of the Second Core Lab of Department of Medical Research in National Taiwan University Hospital for technical assistance. ",

year = "2012",

month = mar,

doi = "10.1016/j.atherosclerosis.2011.12.003",

language = "???core.languages.en_GB???",

volume = "221",

pages = "154--159",

journal = "Atherosclerosis",

issn = "0021-9150",

number = "1",

}

TY - JOUR

T1 - Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma

AU - Lin, Yen Hung

AU - Lin, Lian Yu

AU - Chen, Aaron

AU - Wu, Xue Ming

AU - Lee, Jen Kuang

AU - Su, Ta Chen

AU - Wu, Vin Cent

AU - Chueh, Shih Chieh

AU - Lin, Wei Chou

AU - Lo, Men Tzung

AU - Wang, Pa Chun

AU - Ho, Yi Lwun

AU - Wu, Kwan Dun

N1 - Funding Information: This study was supported by Ta-Tung Kidney Foundation, National Taiwan University Hospital ( NTUH 99-M1427 ), Department of Health, Executive Yuan, R.O.C. (Grant DOH 99-TD-B-111-001 ), Taiwan National Science Council (Grants NSC 97-2314-B-002-155-MY2 and NSC 100-2314-B-002-139 ), and Taiwan National Science Council support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan ( NSC 99-2911-I-008-100 ). We thank Ms. Hsien Fen-Fun for medical technologic support and the staff of the Second Core Lab of Department of Medical Research in National Taiwan University Hospital for technical assistance.

PY - 2012/3

Y1 - 2012/3

N2 - Context: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, and is associated with more prominent vascular stiffness and atherosclerosis. However, the effect of adrenalectomy on reversibility of vascular damage is unclear. Objective: Our objective was to investigate the vascular changes and possibility of reversibility after adrenalectomy in PA patients. Methods: We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that received adrenalectomy from October 2006 to December 2008 and 21 patients with essential hypertension (EH) were enrolled as the control group. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound of the right common carotid arteries and pulse wave velocity (PWV) measurement including brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV) were performed in both groups. The follow-up measurements were performed one-year after adrenalectomy in APA group. Results: APA patients had significantly higher diastolic blood pressure, plasma aldosterone concentration (PAC) and aldosterone-renin ratio (ARR), but lower serum potassium level and plasma renin activity (PRA) than EH patients. APA patients had significantly higher CIMT (0.64 ± 0.13 vs. 0.53 ± 0.10. mm, p= 0.006), higher baPWV (1589 ± 296 vs. 1405 ± 187. cm/s, p= 0.024) and haPWV (1095 ± 150 vs. 987 ± 114. cm/s, p= 0.013) comparing with EH patients. One-year after adrenalectomy, CIMT reduced significantly from 0.64 ± 0.13. mm to 0.59 ± 0.14. mm (p= 0.014), and baPWV and haPWV also showed significant reduction (baPWV, 1589 ± 296 to 1463 ± 188. cm/s, p= 0.035; haPWV, 1095 ± 150 to 1017 ± 109. cm/s, p= 0.019). Conclusion: APA patients have higher degree of early atherosclerosis and vascular stiffness. Adrenalectomy not only corrects the high blood pressure and biochemical parameters but also reverse adverse vascular change in APA patients.

AB - Context: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, and is associated with more prominent vascular stiffness and atherosclerosis. However, the effect of adrenalectomy on reversibility of vascular damage is unclear. Objective: Our objective was to investigate the vascular changes and possibility of reversibility after adrenalectomy in PA patients. Methods: We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that received adrenalectomy from October 2006 to December 2008 and 21 patients with essential hypertension (EH) were enrolled as the control group. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound of the right common carotid arteries and pulse wave velocity (PWV) measurement including brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV) were performed in both groups. The follow-up measurements were performed one-year after adrenalectomy in APA group. Results: APA patients had significantly higher diastolic blood pressure, plasma aldosterone concentration (PAC) and aldosterone-renin ratio (ARR), but lower serum potassium level and plasma renin activity (PRA) than EH patients. APA patients had significantly higher CIMT (0.64 ± 0.13 vs. 0.53 ± 0.10. mm, p= 0.006), higher baPWV (1589 ± 296 vs. 1405 ± 187. cm/s, p= 0.024) and haPWV (1095 ± 150 vs. 987 ± 114. cm/s, p= 0.013) comparing with EH patients. One-year after adrenalectomy, CIMT reduced significantly from 0.64 ± 0.13. mm to 0.59 ± 0.14. mm (p= 0.014), and baPWV and haPWV also showed significant reduction (baPWV, 1589 ± 296 to 1463 ± 188. cm/s, p= 0.035; haPWV, 1095 ± 150 to 1017 ± 109. cm/s, p= 0.019). Conclusion: APA patients have higher degree of early atherosclerosis and vascular stiffness. Adrenalectomy not only corrects the high blood pressure and biochemical parameters but also reverse adverse vascular change in APA patients.

KW - Adrenalectomy

KW - Aldosterone producing adenoma

KW - Carotid intima media thickness

KW - Primary aldosteronism

KW - Pulse wave velocity

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U2 - 10.1016/j.atherosclerosis.2011.12.003

DO - 10.1016/j.atherosclerosis.2011.12.003

M3 - 期刊論文

C2 - 22197109

AN - SCOPUS:84857032755

SN - 0021-9150

VL - 221

SP - 154

EP - 159

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma

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