摘要
Bromotrimethylsilane (TMSBr)-promoted intramolecular cyclization of (o-arylethynyl)benzyl ethers to form 1H-isochromenes at room temperature is reported. Further studies indicated that vinyl carbocations are the reaction intermediates which are stabilized by the conjugated aryl groups. Thus, O-addition of benzyl ethers/tetrahydropyrans to alkynes was achieved under metal-free, acidic conditions. These reaction conditions were compatible with an alkynyl Prins reaction; therefore, 1H-isochromenes were produced directly from alkynyl benzaldehydes and alkynyl alcohols using a one-pot procedure. This journal is
原文 | ???core.languages.en_GB??? |
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頁(從 - 到) | 10390-10402 |
頁數 | 13 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 19 |
發行號 | 47 |
DOIs | |
出版狀態 | 已出版 - 21 12月 2021 |