A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes

F. C. Chien, S. J. Chen

研究成果: 雜誌貢獻期刊論文同行評審

186 引文 斯高帕斯(Scopus)

摘要

Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.

原文???core.languages.en_GB???
頁(從 - 到)633-642
頁數10
期刊Biosensors and Bioelectronics
20
發行號3
DOIs
出版狀態已出版 - 15 10月 2004

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