A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Chun Ming Huang; Justin W. Torpey; Yu Tseung Liu; Yun Ru Chen; Katherine E. Williams; Elizabeth A. Komives; Richard L. Gallo

doi:10.1128/AAC.01347-07

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Chun Ming Huang
, Justin W. Torpey
, Yu Tseung Liu
, Yun Ru Chen
, Katherine E. Williams
, Elizabeth A. Komives
, Richard L. Gallo

生醫科學與工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

摘要

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

原文	???core.languages.en_GB???
頁（從 - 到）	1834-1836
頁數	3
期刊	Antimicrobial Agents and Chemotherapy
卷	52
發行號	5
DOIs	https://doi.org/10.1128/AAC.01347-07
出版狀態	已出版 - 5月 2008

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10.1128/AAC.01347-07

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abstract = "Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.",

author = "Huang, \{Chun Ming\} and Torpey, \{Justin W.\} and Liu, \{Yu Tseung\} and Chen, \{Yun Ru\} and Williams, \{Katherine E.\} and Komives, \{Elizabeth A.\} and Gallo, \{Richard L.\}",

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AU - Huang, Chun Ming

AU - Torpey, Justin W.

AU - Liu, Yu Tseung

AU - Chen, Yun Ru

AU - Williams, Katherine E.

AU - Komives, Elizabeth A.

AU - Gallo, Richard L.

PY - 2008/5

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AB - Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

UR - https://www.scopus.com/pages/publications/42949095869

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DO - 10.1128/AAC.01347-07

M3 - 期刊論文

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AN - SCOPUS:42949095869

SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

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IS - 5

ER -

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

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