A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Chun Ming Huang; Justin W. Torpey; Yu Tseung Liu; Yun Ru Chen; Katherine E. Williams; Elizabeth A. Komives; Richard L. Gallo

doi:10.1128/AAC.01347-07

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Chun Ming Huang, Justin W. Torpey, Yu Tseung Liu, Yun Ru Chen, Katherine E. Williams, Elizabeth A. Komives, Richard L. Gallo

生醫科學與工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

摘要

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

原文	???core.languages.en_GB???
頁（從 - 到）	1834-1836
頁數	3
期刊	Antimicrobial Agents and Chemotherapy
卷	52
發行號	5
DOIs	https://doi.org/10.1128/AAC.01347-07
出版狀態	已出版 - 5月 2008

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10.1128/AAC.01347-07

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abstract = "Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.",

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AU - Huang, Chun Ming

AU - Torpey, Justin W.

AU - Liu, Yu Tseung

AU - Chen, Yun Ru

AU - Williams, Katherine E.

AU - Komives, Elizabeth A.

AU - Gallo, Richard L.

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AB - Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

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ER -

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

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