A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis

Pei Feng Liu, Susan Kinder Haake, Richard L. Gallo, Chun Ming Huang

研究成果: 雜誌貢獻期刊論文同行評審

29 引文 斯高帕斯(Scopus)

摘要

An abscess in a gum pocket, resulting from bacterial infection, is a common source of chronic halitosis. Although antibiotics are generally prescribed for abscesses, they require multiple treatments with risks of creating resistant bacterial strains. Here we develop a novel vaccine using ultraviolet-inactivated Fusobacterium nucleatum (F. nucleatum), a representative oral bacterium for halitosis. A gum pocket model, established by continuous inoculation of F. nucleatum, was employed to validate the vaccine potency. Mice immunized with inactivated F. nucleatum effectively minimized the progression of abscesses, measured by swollen tissues of gum pockets. Most notably, the immunized mice were capable of eliciting neutralizing antibodies against the production of volatile sulfur compounds of F. nucleatum. The novel vaccine inducing protective immunity provides an alternative option to conventional antibiotic treatments for chronic halitosis associated with abscesses. Crown

原文???core.languages.en_GB???
頁(從 - 到)1589-1595
頁數7
期刊Vaccine
27
發行號10
DOIs
出版狀態已出版 - 4 3月 2009

指紋

深入研究「A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis」主題。共同形成了獨特的指紋。

引用此