A minimal spatial cell lineage model of epithelium: Tissue stratification and multi-stability

Wei Ting Yeh, Hsuan Yi Chen

研究成果: 雜誌貢獻期刊論文同行評審

2 引文 斯高帕斯(Scopus)

摘要

A minimal model which includes spatial and cell lineage dynamics for stratified epithelia is presented. The dependence of tissue steady state on cell differentiation models, cell proliferation rate, cell differentiation rate, and other parameters are studied numerically and analytically. Our minimal model shows some important features. First, we find that morphogen or mechanical stress mediated interaction is necessary to maintain a healthy stratified epithelium. Furthermore, comparing with tissues in which cell differentiation can take place only during cell division, tissues in which cell division and cell differentiation are decoupled can achieve relatively higher degree of stratification. Finally, our model also shows that in the presence of short-range interactions, it is possible for a tissue to have multiple steady states. The relation between our results and tissue morphogenesis or lesion is discussed.

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文章編號053051
期刊New Journal of Physics
20
發行號5
DOIs
出版狀態已出版 - 5月 2018

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