A common-path phase-shift interferometry surface plasmon resonance imaging system

Y. T. Su, S. J. Chen, T. L. Yeh

研究成果: 雜誌貢獻會議論文同行評審

2 引文 斯高帕斯(Scopus)


A biosensing imaging system is proposed based on the integration of surface plasmon resonance (SPR) and common-path phase-shift interferometry (PSI) techniques to measure the two-dimensional spatial phase variation caused by biomolecular interactions upon a sensing chip. The SPR phase imaging system can offer high resolution and high-throughout screening capabilities to analyze microarray biomolecular interaction without the need for additional labeling. With the long-term stability advantage of the common-path PSI technique even with external disturbances such as mechanical vibration, buffer flow noise, and laser unstable issue, the system can match the demand of real-time kinetic study for biomolecular interaction analysis (BIA). The SPR-PSI imaging system has achieved a detection limit of 2×10-7 refraction index change, a long-term phase stability of 2.5×10-4μ rms over four hours, and a spatial phase resolution of 10-3 π with a lateral resolution of 100μm.

頁(從 - 到)144-151
期刊Progress in Biomedical Optics and Imaging - Proceedings of SPIE
出版狀態已出版 - 2005
事件Plasmonics in Biology and Medicine II - San Jose, CA, United States
持續時間: 24 1月 200525 1月 2005


深入研究「A common-path phase-shift interferometry surface plasmon resonance imaging system」主題。共同形成了獨特的指紋。