每年專案
摘要
Background. Recovery of upper limb function post-stroke can be partly predicted by initial motor function, but the mechanisms underpinning these improvements have yet to be determined. Here, we sought to identify neural correlates of post-stroke recovery using longitudinal magnetoencephalography (MEG) assessments in subacute stroke survivors. Methods. First-ever, subcortical ischemic stroke survivors with unilateral mild to moderate hand paresis were evaluated at 3, 5, and 12 weeks after stroke using a finger-lifting task in the MEG. Cortical activity patterns in the β-band (16-30 Hz) were compared with matched healthy controls. Results. All stroke survivors (n=22; 17 males) had improvements in action research arm test (ARAT) and Fugl-Meyer upper extremity (FM-UE) scores between 3 and 12 weeks. At 3 weeks post-stroke the peak amplitudes of the movement-related ipsilesional β-band event-related desynchronization (β-ERD) and synchronization (β-ERS) in primary motor cortex (M1) were significantly lower than the healthy controls (p<0.001) and were correlated with both the FM-UE and ARAT scores (r=0.51-0.69, p<0.017). The decreased β-ERS peak amplitudes were observed both in paretic and non-paretic hand movement particularly at 3 weeks post-stroke, suggesting a generalized disinhibition status. The peak amplitudes of ipsilesional β-ERS at week 3 post-stroke correlated with the FM-UE score at 12 weeks (r=0.54, p=0.03) but no longer significant when controlling for the FM-UE score at 3 weeks post-stroke.Conclusions. Although early β-band activity does not independently predict outcome at 3 months after stroke, it mirrors functional changes, giving a potential insight into the mechanisms underpinning recovery of motor function in subacute stroke.
原文 | ???core.languages.en_GB??? |
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頁(從 - 到) | 450-462 |
頁數 | 13 |
期刊 | Neurorehabilitation and Neural Repair |
卷 | 34 |
發行號 | 5 |
DOIs | |
出版狀態 | 已出版 - 1 5月 2020 |
指紋
深入研究「β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke」主題。共同形成了獨特的指紋。專案
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應用於居家照護之智慧型互動平台-應用於醫療場域及居家照護之智慧 型互動平台- 以人工智慧為核心之腦波人機介面開發(2/4)
Shyu, K.-K. (PI)
1/01/19 → 31/12/19
研究計畫: Research
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應用於居家照護之智慧型互動平台-應用於醫療場域及居家照護之智慧 型互動平台- 以人工智慧為核心之腦波人機介面開發(1/4)
Shyu, K.-K. (PI)
1/01/18 → 31/12/18
研究計畫: Research
資料集
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Supplementary – Supplemental material for β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke
Hsiao, F.-J. (貢獻者), Stagg, C. J. (貢獻者), Tsai, Y.-A. (貢獻者), Tang, C.-W. (貢獻者), Lin, Y.-Y. (貢獻者), Lee, P.-L. (貢獻者), Lee, I.-H. (貢獻者), Hsu, Y.-F. (貢獻者) & Chen, W.-T. (貢獻者), figshare SAGE Publications, 1 1月 2020
DOI: 10.25384/sage.12191379.v1, https://doi.org/10.25384%2Fsage.12191379.v1
資料集
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β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke
Tang, C.-W. (???dataset.roles.dataset.creator???), Hsiao, F.-J. (貢獻者), Lee, P.-L. (貢獻者), Tsai, Y.-A. (貢獻者), Hsu, Y.-F. (???dataset.roles.dataset.creator???), Chen, W.-T. (貢獻者), Lin, Y.-Y. (貢獻者), Stagg, C. J. (???dataset.roles.dataset.creator???) & Lee, I.-H. (貢獻者), SAGE Journals, 2020
DOI: 10.25384/sage.c.4951623.v1, https://sage.figshare.com/collections/_-Oscillations_Reflect_Recovery_of_the_Paretic_Upper_Limb_in_Subacute_Stroke/4951623/1
資料集
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β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke
Tang, C.-W. (???dataset.roles.dataset.creator???), Hsiao, F.-J. (貢獻者), Lee, P.-L. (貢獻者), Tsai, Y.-A. (貢獻者), Hsu, Y.-F. (???dataset.roles.dataset.creator???), Chen, W.-T. (貢獻者), Lin, Y.-Y. (貢獻者), Stagg, C. J. (???dataset.roles.dataset.creator???) & Lee, I.-H. (貢獻者), figshare SAGE Publications, 2020
DOI: 10.25384/sage.c.4951623.v1, https://sage.figshare.com/collections/_-Oscillations_Reflect_Recovery_of_the_Paretic_Upper_Limb_in_Subacute_Stroke/4951623/1
資料集