Additional file 7: Figure S4. of Epigenetic assimilation in the aging human brain

Permuted null distribution of mean domain length. The histogram represents the densities of the permuted null distribution from all samples and the red dashed line is the mean domain length in the indicated subset sample of interest (i.e., older individuals (>75 years), EAO cortex, or AD buccal cells). a Mean DNA modification domain length of older individual in the cerebral cortex (permuted p = 0.01). b Mean DNA modification domain length of older individual in the cerebellum (permuted p = 0.13). c Mean domain length of older individual transcriptome in the cerebral cortex (permuted p = 0.01). d Mean domain length of older individual transcriptome in the cerebellum (permuted p = 0.51). e Mean domain length of the EAO cerebral cortex (permuted p = 0.015). f Mean domain length of the AD-affected twin buccal samples (permuted p = 0.04). (PDF 131 kb)