Permuted null distribution of mean ICC in AD twin samples. ICC densities of the permuted null from all samples compared with the mean ICC in the indicated subset sample of interest (red dashed line). a EAO cortex versus cerebellum using the top 5 % of differentially modified loci (permuted p = 0.014). b EAO cortex versus cerebellum using the bottom 5 % of differentially modified loci (permuted p = 0.51). c EAO cortex versus cerebellum using the nominally significant (p