Zwitterionic fibrous polypropylene assembled with amphiphatic carboxybetaine copolymers for hemocompatible blood filtration

Antoine Venault, Chih Chen Ye, Yi Cun Lin, Ching Wei Tsai, Jheng Fong Jhong, Ruoh Chyu Ruaan, Akon Higuchi, Arunachalam Chinnathambi, Hsin Tsung Ho, Yung Chang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The present study serves three main functions. First, it presents a novel random copolymer, made of octadecyl acrylate hydrophobic blocks and 2-(dimethylamino)ethyl methacrylate hydrophilic groups, and it zwitterionic form. Second, random copolymer and zwitterionic random copolymer, OmDn and Z-OmDn, are used to modify polypropylene membranes by evaporation coating. Our investigations unveil that this method leads to sufficiently stable self-assembling provided a minimum number of hydrophobic repeat units of 77, which also corresponds to a hydrophobic degree of 74%. Third, antifouling and hemocompatible properties of membranes are thoroughly investigated using all types of blood cells separately, as well as challenging membranes against whole blood in static and dynamic conditions. Membranes modified with zwitterionic copolymer containing 26% of zwitterionic groups are shown to be highly antifouling and hemocompatible, for a coating density as low as 0.2 mg/cm2. Their application in a specially designed blood filtration module enabled to almost totally inhibit blood cells interactions with membrane material, as well as to importantly reduce platelet activation in the permeate (2.5-fold reduction). Statement of Significance The design of new zwitterionic copolymer material is proposed and demonstrated in this study. It was showed that hydrophobicoctadecyl acrylate segments can be introduced in the zwitterioniccarboxybetaine polymer chain with a well-controlled random sequence. Stable, efficient, and effective surface zwitterionization of hydrophobic polypropylene are obtained via grafting onto approach by evaporation-induced self-assembling coating. In the perspective of potential application, hemocompatible blood filtration was demonstrated with the excellent results of non-activated platelets obtained. Summary of Impacts Design: New zwitterionicmaterial, amphiphatic carboxybetaine copolymers. Development: Evaporation-induced self-assembling grafting. Application: Hemocompatible blood filtration.

Original languageEnglish
Pages (from-to)130-141
Number of pages12
JournalActa Biomaterialia
Volume40
DOIs
StatePublished - 1 Aug 2016

Keywords

  • Amphiphatic copolymer
  • Antifouling properties
  • Blood filtration
  • Hemocompatible polypropylene membrane
  • Solvent evaporation

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