TY - JOUR
T1 - VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population
AU - Lee, Shih Wei
AU - Chuang, Tzu Yi
AU - Huang, Hsiu Han
AU - Liu, Chi Wei
AU - Kao, Yung Hsi
AU - Wu, Lawrence Shih Hsin
N1 - Publisher Copyright:
© 2016
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB. Methods We typed four VDR polymorphisms of restriction endonuclease sites for ApaI, TaqI, BsmI, and FokI and three VDBP polymorphisms—Thr420Lys, Asp416Glu, and Cys299Cys—in 198 patients with TB and 170 healthy volunteers. Results VDR TaqI, VDR BsmI, and VDBP Asp416Glu were significantly associated with TB susceptibility. Odd ratios of risk genotypes of the above three polymorphisms were 2.16 (95% confidence interval 1.01, 4.65), 2.14 (95% confidence interval 1.06, 4.31), and 2.24 (95% confidence interval 1.04, 4.80), respectively. VDBP haplotype analysis showed Gc1f carriers associated to TB. Conclusion The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population.
AB - Background The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB. Methods We typed four VDR polymorphisms of restriction endonuclease sites for ApaI, TaqI, BsmI, and FokI and three VDBP polymorphisms—Thr420Lys, Asp416Glu, and Cys299Cys—in 198 patients with TB and 170 healthy volunteers. Results VDR TaqI, VDR BsmI, and VDBP Asp416Glu were significantly associated with TB susceptibility. Odd ratios of risk genotypes of the above three polymorphisms were 2.16 (95% confidence interval 1.01, 4.65), 2.14 (95% confidence interval 1.06, 4.31), and 2.24 (95% confidence interval 1.04, 4.80), respectively. VDBP haplotype analysis showed Gc1f carriers associated to TB. Conclusion The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population.
KW - VDBP
KW - VDR
KW - polymorphism
KW - tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84956879792&partnerID=8YFLogxK
U2 - 10.1016/j.jmii.2015.12.008
DO - 10.1016/j.jmii.2015.12.008
M3 - 期刊論文
C2 - 26869016
AN - SCOPUS:84956879792
SN - 1684-1182
VL - 49
SP - 783
EP - 787
JO - Journal of Microbiology, Immunology and Infection
JF - Journal of Microbiology, Immunology and Infection
IS - 5
ER -