Use of nanoparticles as therapy for methicillin-resistant Staphylococcus aureus infections

Pei Feng Liu, Chih Wei Lo, Chao Hsuan Chen, Ming Fa Hsieh, Chun Ming Huang

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Staphylococcal infection can cause a wide range of diseases resulting either from staphylococcal bacteria invasion or through toxin production. The majority of infections caused by staphylococci are due to Staphylococcus aureus. Moreover, methicillin-resistant Staphylococcus aureus has recently been considered to be one of the major causes of hospital-acquired infections. The treatment of staphylococci infections is difficult because increased antibiotic resistant strains have become more common, increasing the risk of serious health penalty. Delivery of antibiotics via nanoparticles is a promising therapy, as a drug delivery mechanism, particularly for controlled release or depot delivery of drugs to decrease the number of doses required to achieve a clinical effect. This review emphasized the potential of nanoparticles in the targeted antibiotics for therapy of staphylococcal infections.

Original languageEnglish
Pages (from-to)875-884
Number of pages10
JournalCurrent Drug Metabolism
Volume10
Issue number8
DOIs
StatePublished - Oct 2009

Keywords

  • Antibiotic therapy
  • Methicillin-resistant Staphylococcus aureus
  • Nanoparticles
  • Staphylococcal infections
  • Staphylococcus aureus

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