Unzipping of DNA with correlated base sequence

A. E. Allahverdyan; Zh S. Gevorkian; Chin Kun Hu; Ming Chya Wu

doi:10.1103/PhysRevE.69.061908

Unzipping of DNA with correlated base sequence

A. E. Allahverdyan, Zh S. Gevorkian, Chin Kun Hu, Ming Chya Wu

Department of Physics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base pairs displays two widely different scenarios depending on the details of the base sequence: either there is no unzipping phase transition at all, or the transition is realized via a sequence of jumps with magnitude comparable to the size of the system. Both scenarios are different from the behavior of the average number of unzipped base pairs (non-self-averaging). The results can be relevant for explaining the biological purpose of correlated structures in DNA.

Original language	English
Pages (from-to)	16
Number of pages	1
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	69
Issue number	6
DOIs	https://doi.org/10.1103/PhysRevE.69.061908
State	Published - 2004

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10.1103/PhysRevE.69.061908

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title = "Unzipping of DNA with correlated base sequence",

abstract = "We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base pairs displays two widely different scenarios depending on the details of the base sequence: either there is no unzipping phase transition at all, or the transition is realized via a sequence of jumps with magnitude comparable to the size of the system. Both scenarios are different from the behavior of the average number of unzipped base pairs (non-self-averaging). The results can be relevant for explaining the biological purpose of correlated structures in DNA.",

author = "Allahverdyan, {A. E.} and Gevorkian, {Zh S.} and Hu, {Chin Kun} and Wu, {Ming Chya}",

note = "Funding Information: This work of Zh.S.G., C.-K.H., and W.-C.W. was supported in part by a grant from National Science Council in Taiwan under Grant No. NSC 92-2112-M-001-063. The work of A.E. A. was part of the research programme of the Stichting voor Fundamenteel Onderzoek der Materie [FOM, financially supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)]. Zh.S.G. acknowledges interesting discussions with A. Maritan and D. Marenduzzo.",

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AU - Allahverdyan, A. E.

AU - Gevorkian, Zh S.

AU - Hu, Chin Kun

AU - Wu, Ming Chya

N1 - Funding Information: This work of Zh.S.G., C.-K.H., and W.-C.W. was supported in part by a grant from National Science Council in Taiwan under Grant No. NSC 92-2112-M-001-063. The work of A.E. A. was part of the research programme of the Stichting voor Fundamenteel Onderzoek der Materie [FOM, financially supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)]. Zh.S.G. acknowledges interesting discussions with A. Maritan and D. Marenduzzo.

PY - 2004

Y1 - 2004

N2 - We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base pairs displays two widely different scenarios depending on the details of the base sequence: either there is no unzipping phase transition at all, or the transition is realized via a sequence of jumps with magnitude comparable to the size of the system. Both scenarios are different from the behavior of the average number of unzipped base pairs (non-self-averaging). The results can be relevant for explaining the biological purpose of correlated structures in DNA.

AB - We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base pairs displays two widely different scenarios depending on the details of the base sequence: either there is no unzipping phase transition at all, or the transition is realized via a sequence of jumps with magnitude comparable to the size of the system. Both scenarios are different from the behavior of the average number of unzipped base pairs (non-self-averaging). The results can be relevant for explaining the biological purpose of correlated structures in DNA.

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VL - 69

SP - 16

JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

IS - 6

ER -

Unzipping of DNA with correlated base sequence

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