Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

Dhanang Edy Pratama; Wen Chen Hsieh; Kuan Yun Lin; Yu Ying Chen; Chun Chou Lin; Tu Lee; Yufang Hu

doi:10.1080/01496395.2020.1837876

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

Dhanang Edy Pratama, Wen Chen Hsieh, Kuan Yun Lin, Yu Ying Chen, Chun Chou Lin, Tu Lee, Yufang Hu

Department of Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

An unconventional arsenic trioxide (As₂O₃) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As₂O₃/mL of H₂O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As₂O₃ solids recovered were 60 to 90 wt% with a purity in conformity with the As₂O₃ standard based on an HPLC assay. The recovered As₂O₃ solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

Original language	English
Pages (from-to)	2634-2647
Number of pages	14
Journal	Separation Science and Technology
Volume	56
Issue number	15
DOIs	https://doi.org/10.1080/01496395.2020.1837876
State	Published - 2021

Keywords

Arsenic recovery
Evaporative crystallization
Unused chemotherapeutic agents

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10.1080/01496395.2020.1837876

Drug Recycle:Recovery of Active Pharmaceutical Ingredients from Various Medication Using Solvent Extraction and Recrystallization( II )
Lee, T. (PI)
1/12/19 → 30/11/20
Project: Research
Drug Recycle:Recovery of Active Pharmaceutical Ingredients from Various Medication Using Solvent Extraction and Recrystallization( I )(2/2)
Lee, T. (PI)
1/12/19 → 30/11/20
Project: Research

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization
Pratama, D. E. (Contributor), Hsieh, W.-C. (Contributor), Lin, K.-Y. (Contributor), Lee, T. (Contributor), Chen, Y.-Y. (Contributor), Hu, Y. (Contributor) & Lin, C.-C. (Contributor), figshare Academic Research System, 1 Jan 2020
DOI: 10.6084/m9.figshare.13168155.v1, https://tandf.figshare.com/articles/journal_contribution/Unconventional_separation_of_arsenic_trioxide_from_unused_aqueous_chemotherapeutic_agents_by_direct_evaporative_crystallization/13168155/1
Dataset

Cite this

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title = "Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization",

abstract = "An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.",

keywords = "Arsenic recovery, Evaporative crystallization, Unused chemotherapeutic agents",

author = "Pratama, {Dhanang Edy} and Hsieh, {Wen Chen} and Lin, {Kuan Yun} and Chen, {Yu Ying} and Lin, {Chun Chou} and Tu Lee and Yufang Hu",

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T1 - Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

AU - Pratama, Dhanang Edy

AU - Hsieh, Wen Chen

AU - Lin, Kuan Yun

AU - Chen, Yu Ying

AU - Lin, Chun Chou

AU - Lee, Tu

AU - Hu, Yufang

PY - 2021

Y1 - 2021

N2 - An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

AB - An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

KW - Arsenic recovery

KW - Evaporative crystallization

KW - Unused chemotherapeutic agents

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DO - 10.1080/01496395.2020.1837876

M3 - 期刊論文

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SN - 0149-6395

VL - 56

SP - 2634

EP - 2647

JO - Separation Science and Technology

JF - Separation Science and Technology

IS - 15

ER -

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

Abstract

Keywords

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Projects

Drug Recycle:Recovery of Active Pharmaceutical Ingredients from Various Medication Using Solvent Extraction and Recrystallization( II )

Drug Recycle:Recovery of Active Pharmaceutical Ingredients from Various Medication Using Solvent Extraction and Recrystallization( I )(2/2)

Datasets

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

Cite this