Total synthesis of (+)-Valyldetoxinine and (-)-detoxin D1

Wen Ren Li, So Yeop Han, Madeleine M. Joullié

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The detoxin complex, metabolites produced by Streptomyces caespitosus var. detoxicus 7072 GC1, is a selective antagonist of the antibiotic blasticidin S. Two approaches toward the total synthesis of (+)-valyldetoxinine and (-)-detoxin D1 are described. These routes involve a 2,3-disubstituted pyrrolidine as a common intermediate and utilize glucose as the chiral precursor.

Original languageEnglish
Pages (from-to)785-802
Number of pages18
JournalTetrahedron
Volume49
Issue number4
DOIs
StatePublished - 22 Jan 1993

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