Total synthesis of quebrachamine through macrolactamization

Keyphrases

• Total Synthesis 100%
• Macrolactonization 100%
• Quebrachamine 100%
• Indole 66%
• Commercially Available 33%
• Hydrogenation 33%
• Lithium 33%
• Piperidine 33%
• Homocoupling 33%
• Alkynes 33%
• Lactams 33%
• CIS2 33%
• GLA-SE 33%
• Copper Iodide 33%
• Sonogashira Reaction 33%
• Direct Approach 33%
• Sonogashira Coupling 33%

Chemistry

• Indole 100%
• Hydrogenation 50%
• Lithium 50%
• Piperidine 50%
• Sonogashira Cross-Coupling 50%
• Alkyne 50%
• Lactam 50%