Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells

I. Ni Chen; Prasanna Kumar Ganta; Shou Jie Chung; Yu Lun Chang; Heng Yi Chang; Shangwu Ding; Hsuan Ying Chen; Chien Chih Chiu; Kuo Hui Wu

doi:10.1002/jccs.202000393

Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells

I. Ni Chen, Prasanna Kumar Ganta, Shou Jie Chung, Yu Lun Chang, Heng Yi Chang, Shangwu Ding, Hsuan Ying Chen, Chien Chih Chiu, Kuo Hui Wu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (^HL^MeTi-O)₄ (IC₅₀ = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.

Original language	English
Pages (from-to)	871-877
Number of pages	7
Journal	Journal of the Chinese Chemical Society
Volume	68
Issue number	5
DOIs	https://doi.org/10.1002/jccs.202000393
State	Published - May 2021

Keywords

2,6-bis(o-hydroxyalkyl)pyridine ligand
in vitro cytotoxicity
nonplatinum complex
pincer complexes
titanium complex
TNBC cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jccs.202000393

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title = "Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells",

abstract = "Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (HLMeTi-O)4 (IC50 = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.",

keywords = "2,6-bis(o-hydroxyalkyl)pyridine ligand, in vitro cytotoxicity, nonplatinum complex, pincer complexes, titanium complex, TNBC cell",

author = "Chen, {I. Ni} and Ganta, {Prasanna Kumar} and Chung, {Shou Jie} and Chang, {Yu Lun} and Chang, {Heng Yi} and Shangwu Ding and Chen, {Hsuan Ying} and Chiu, {Chien Chih} and Wu, {Kuo Hui}",

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year = "2021",

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doi = "10.1002/jccs.202000393",

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volume = "68",

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T1 - Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells

AU - Chen, I. Ni

AU - Ganta, Prasanna Kumar

AU - Chung, Shou Jie

AU - Chang, Yu Lun

AU - Chang, Heng Yi

AU - Ding, Shangwu

AU - Chen, Hsuan Ying

AU - Chiu, Chien Chih

AU - Wu, Kuo Hui

PY - 2021/5

Y1 - 2021/5

N2 - Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (HLMeTi-O)4 (IC50 = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.

AB - Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (HLMeTi-O)4 (IC50 = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.

KW - 2,6-bis(o-hydroxyalkyl)pyridine ligand

KW - in vitro cytotoxicity

KW - nonplatinum complex

KW - pincer complexes

KW - titanium complex

KW - TNBC cell

UR - http://www.scopus.com/inward/record.url?scp=85099867451&partnerID=8YFLogxK

U2 - 10.1002/jccs.202000393

DO - 10.1002/jccs.202000393

M3 - 期刊論文

AN - SCOPUS:85099867451

SN - 0009-4536

VL - 68

SP - 871

EP - 877

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 5

ER -

Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells

Abstract

Keywords

UN SDGs

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