Abstract
An amine-catalyzed, one-pot synthesis of thioesters directly from carboxylic acids, thioureas, and Michael acceptors is described. This process was further improved by use of 1-[2-(methylamino)ethyl]-3-phenylthiourea (4) as the catalyst. Aromatic and aliphatic carboxylic acids with functional groups are compatible with this process, and both α,β-unsaturated esters and ketones can be the Michael acceptors for this reaction. The progress of this reaction was monitored by 1H NMR, and a reaction mechanism is proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 2644-2650 |
| Number of pages | 7 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 357 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Aug 2015 |
Keywords
- Michael addition
- multicomponent reaction
- organic catalysis
- thioesterification