TY - JOUR
T1 - Thioesterifications Free of Activating Agent and Thiol
T2 - A Three-Component Reaction of Carboxylic Acids, Thioureas, and Michael Acceptors
AU - Swain, Sharada Prasanna
AU - Chou, Yen Lin
AU - Hou, Duen Ren
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - An amine-catalyzed, one-pot synthesis of thioesters directly from carboxylic acids, thioureas, and Michael acceptors is described. This process was further improved by use of 1-[2-(methylamino)ethyl]-3-phenylthiourea (4) as the catalyst. Aromatic and aliphatic carboxylic acids with functional groups are compatible with this process, and both α,β-unsaturated esters and ketones can be the Michael acceptors for this reaction. The progress of this reaction was monitored by 1H NMR, and a reaction mechanism is proposed.
AB - An amine-catalyzed, one-pot synthesis of thioesters directly from carboxylic acids, thioureas, and Michael acceptors is described. This process was further improved by use of 1-[2-(methylamino)ethyl]-3-phenylthiourea (4) as the catalyst. Aromatic and aliphatic carboxylic acids with functional groups are compatible with this process, and both α,β-unsaturated esters and ketones can be the Michael acceptors for this reaction. The progress of this reaction was monitored by 1H NMR, and a reaction mechanism is proposed.
KW - Michael addition
KW - multicomponent reaction
KW - organic catalysis
KW - thioesterification
UR - http://www.scopus.com/inward/record.url?scp=84939824584&partnerID=8YFLogxK
U2 - 10.1002/adsc.201500426
DO - 10.1002/adsc.201500426
M3 - 期刊論文
AN - SCOPUS:84939824584
SN - 1615-4150
VL - 357
SP - 2644
EP - 2650
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 12
ER -