Thermo-mechanical fatigue (TMF) behavior of a joint between a solid oxide fuel cell glass-ceramic sealant and an interconnect steel is investigated in a reducing atmosphere (H2-7 vol% H2O) under cyclic shear and tensile loadings combined with cyclic temperature change between 40°C and 800°C. Experimental results indicate TMF life of shear specimen is increased with a decrease in the end stress applied at 800°C which dominates the shear TMF life. The accumulated duration of loading at peak temperature range (795-800°C) in TMF test is comparable with the estimated creep rupture time at 800°C for shear specimens. TMF fracture of the shear specimens mainly occurs at the interface between the glass-ceramic layer and chromia layer. For tensile specimens, TMF life is controlled by the end stresses applied at 800°C and 40°C. For tensile TMF specimens, fracture mostly takes place within the glass-ceramic layer and at the chromia/glass-ceramic interface.