The heat source from cold cathode fluorescent lamps (CCFLs) in the backlight module of a TFT-LCD TV causes the cell assembly to warpage. The extruding phenomenon, appearing between the cell and its bezel, leads to defects in display of the TFT-LCD TV. The study successfully simulates and predicts the process by finite element analysis (FEA), computational fluid dynamics (CFD), and structure-heat transfer. The paper also shows the efficient experimental verification which uses kinds of physical sensors to measure the temperature variation and thermal stresses on the surface of LCD-TV cell. The achievements and techniques can be employed to analyze and design the geometric parameters of different components in LCD-TV modules for product optimization.