The detoxin complex.-A naturally occurring safener

Wen Ren Li, So Yeop Hant, Madeleine M. Joullié

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The detoxin complex is a group of depsipeptide metabolites produced by the organism Streptomyces caespitosus var. detoxicus 7072 GC1 as well as other strains of Streptomyces. The complex is the first isolated natural product which displays a unique detoxification effect in plant and animal cells as its biological activity. The structural investigations carried out to elucidate the structures of the congeners and the stereochemistry of the stereogenic centers are described. Structure-activity relationships are discussed. The different synthetic approaches to the parent amino acid, (-)detoxinine, are compared. The syntheses of detoxins (-)-B1, (-)-B3, (-)-D1, and(+)-valyldetoxinine are described.

Original languageEnglish
Pages (from-to)359-388
Number of pages30
JournalHeterocycles
Volume36
Issue number2
DOIs
StatePublished - 1 Feb 1993

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