Temperature-responsive hydrogel-coated gold nanoshells

Hye Hun Park, La Ongnuan Srisombat, Andrew C. Jamison, Tingting Liu, Maria D. Marquez, Hansoo Park, Sungbae Lee, Tai Chou Lee, T. Randall Lee

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Gold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at ~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring.

Original languageEnglish
Article number28
Issue number2
StatePublished - Jun 2018


  • Drug delivery
  • Gold nanoshell
  • Hydrogel coating
  • Temperature responsive


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