Synthetic studies of a didemnin B analog based on a 2,3-diamino sugar scaffolding

Joshi M. Ramanjulu, Madeleine M. Joullié, Wen Ren Li

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Reductive amination, amide formation using BOP [(1H-1,2,3-benzotriazol-1-yloxy)tris(dimethyl-amino)-phosphonium hexafluorophosphate] and esterification via DCC (dicyclohexylcarbodiimide) were the key synthetic steps to generate an advanced intermediate in the preparation of a didemnin B analog based on a sugar scaffolding (2). This analog should provide insight into the bioactive conformation of didemnin B.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJournal of the Chinese Chemical Society
Volume48
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Bioactive conformation
  • Cyclodepsipeptide
  • Didemnin B
  • Molecular modeling
  • Sugar scaffolding

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