Synthetic studies of a constrained ring didemnin analog

Scott C. Mayor, Amy J. Pfizenmayer, Richard Cordova, Wen Ren Li, Madeleine M. Joullié

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

An asymmetric Diels-Alder reaction in the presence of 3.0 M lithium perchlorate-diethyl ether was used to generate the initial stereochemistry for a cyclohexane amino acid (3), a key intermediate in the preparation of a fused ring didemnin analog. This constrained ring macrocycle should provide insight into the binding site conformation of the bioactive species.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalTetrahedron: Asymmetry
Volume5
Issue number4
DOIs
StatePublished - Apr 1994

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