Synthesis of (+)-Cladospolide C

Chun Yi Chou, Duen Ren Hou

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


(+)-Cladospolide C was synthesized in eight steps with 5% total yield, using methyl acrylate, (3R,4R)-1,5-hexadiene-3,4-diol, and (6R)-6-hepten-2-ol as the starting materials. Two cross-metathesis reactions and Yamaguchi esterification were applied to assemble the three units into (+)-Cladospolide C. Unsuccessful routes using ring-closing metathesis are also discussed.

Original languageEnglish
Pages (from-to)9887-9890
Number of pages4
JournalJournal of Organic Chemistry
Issue number26
StatePublished - 22 Dec 2006


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