Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen; T. H. Li; S. M. Song; Y. C. Liao; P. H. Tsai; P. C. Wong; V. C. Nguyen; J. S.C. Jang

doi:10.1016/j.matlet.2019.126650

Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen, T. H. Li, S. M. Song, Y. C. Liao, P. H. Tsai, P. C. Wong, V. C. Nguyen, J. S.C. Jang

Graduate Institute of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

Original language	English
Article number	126650
Journal	Materials Letters
Volume	256
DOIs	https://doi.org/10.1016/j.matlet.2019.126650
State	Published - 1 Dec 2019

Keywords

Amorphous materials
Biomaterials
Hot-pressing
Mechanical property
Porous materials

Access to Document

10.1016/j.matlet.2019.126650

Development of the Open-Cell Toxic-Element-Free Ti-Based Bulk Metallic Glass Foams(3/3)
Jang, S.-C. (PI)
1/08/18 → 31/07/19
Project: Research
孔洞漸層之客製化海綿骨置換體開發-孔洞漸層之客製化海綿骨置換體開發(1/3)
Jang, S.-C. (PI)
1/09/17 → 31/07/18
Project: Research

Cite this

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title = "Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application",

abstract = "A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.",

keywords = "Amorphous materials, Biomaterials, Hot-pressing, Mechanical property, Porous materials",

author = "Nguyen, {V. T.} and Li, {T. H.} and Song, {S. M.} and Liao, {Y. C.} and Tsai, {P. H.} and Wong, {P. C.} and Nguyen, {V. C.} and Jang, {J. S.C.}",

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TY - JOUR

T1 - Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

AU - Nguyen, V. T.

AU - Li, T. H.

AU - Song, S. M.

AU - Liao, Y. C.

AU - Tsai, P. H.

AU - Wong, P. C.

AU - Nguyen, V. C.

AU - Jang, J. S.C.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

AB - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

KW - Amorphous materials

KW - Biomaterials

KW - Hot-pressing

KW - Mechanical property

KW - Porous materials

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U2 - 10.1016/j.matlet.2019.126650

DO - 10.1016/j.matlet.2019.126650

M3 - 期刊論文

AN - SCOPUS:85071979170

SN - 0167-577X

VL - 256

JO - Materials Letters

JF - Materials Letters

M1 - 126650

ER -

Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

Abstract

Keywords

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Projects

Development of the Open-Cell Toxic-Element-Free Ti-Based Bulk Metallic Glass Foams(3/3)

孔洞漸層之客製化海綿骨置換體開發-孔洞漸層之客製化海綿骨置換體開發(1/3)

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