Synthesis of 2,3-dihydro-1: H -pyrroles by intramolecular cyclization of N -(3-butynyl)-sulfonamides

Min Ching Chung, Yung Hsiang Chan, Wen Jung Chang, Duen Ren Hou

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Hydroamination of 3-butynamine derivatives to give non-aromatic 2,3-dihydropyrroles was achieved by using PdCl2 or AuCl as the catalyst. With microwave-assisted heating, up to 92% isolated yield was obtained from this intramolecular 5-endo-dig cyclisation. The cyclopentane- and cyclohexane-fused 2,3-dihydropyrroles were transformed into the corresponding N-tosyl-pyrrolidine-2-carboxylic acids.

Original languageEnglish
Pages (from-to)3783-3790
Number of pages8
JournalOrganic and Biomolecular Chemistry
Issue number17
StatePublished - 2017


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