Abstract
Three types of amphiphilic copolymers using n-butylmethacrylate (BMA) as a hydrophobic monomer, and each of N,N′-dimethylacrylamide (DMA), N-acryloylmorpholine (AMO) and N-vinylpyrrolidone (VP) as hydrophilic co-monomers were synthesized for coating filters used to remove leukocytes. The influence of the amphiphilic property of the resulting filters, which were composed of non-woven fabrics coated with the above copolymers, on leukocyte removal and platelet permeation through the filters from whole blood was investigated. The filters coated with poly(AMO-co-BMA) and poly(DMA-co-BMA) showed more than 80% platelet permeation ratio, while the platelet permeation ratio through hydrophobic non-coated filters was only 0.2%. On the other hand, the coated filters showed slightly a higher permeation ratio of leukocytes than did the non-coated filters.
Original language | English |
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Pages | 2108 |
Number of pages | 1 |
State | Published - 2006 |
Event | 55th SPSJ Annual Meeting - Nagoya, Japan Duration: 24 May 2006 → 26 May 2006 |
Conference
Conference | 55th SPSJ Annual Meeting |
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Country/Territory | Japan |
City | Nagoya |
Period | 24/05/06 → 26/05/06 |
Keywords
- Amphiphilic
- Blood cell separation
- Copolymer
- Leukocyte removal
- Permeation of platelets