Syntheses of acyclic analogs of didemnin B

Joshi M. Ramanjulu, Madeleine M. Joullié, Wen Ren Li

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The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (Ist) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine. D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.

Original languageEnglish
Pages (from-to)3259-3272
Number of pages14
JournalSynthetic Communications
Issue number18
StatePublished - 1997


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