Study of photon migration with various sourcedetector separations in near-infrared spectroscopic brain imaging based on threedimensional monte carlo modeling

Cheng Kuang Lee, Chia Wei Sun, Po Lei Lee, Hsiang Chieh Lee, C. C. Yang, Cho Pei Jiang, Yuh Ping Tong, Tzu Chen Yeh, Jen Chuen Hsieh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We have simulated the photon migration with various sourcedetector separations based on a three-dimensional Monte Carlo code. The whole brain MRI structure images are introduced in the simulation, and the brain model is more accurate then the previous studies. The brain model consists of scalp, skull, CSF layer, gray matter, and white matter. We demonstrate dynamic propagating movies under different source-detector separations. The multiple backscattered intensity from every layer of the brain model is obtained by marking the deepest layer which every photon can reach. Also the influences of an absorption target on brain cortex are revealed.

Original languageEnglish
Pages (from-to)8339-8348
Number of pages10
JournalOptics Express
Volume13
Issue number21
DOIs
StatePublished - 17 Oct 2005

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