Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile

Ying Tsang Lu; Yu Xlang Zeng; Wu Xiong Tsai; Hsin Chang Huang; Ming Yuan Tsai; Yong Diao; Wei Hsuan Hung

doi:10.1021/acsomega.4c00722

Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile

Ying Tsang Lu, Yu Xlang Zeng, Wu Xiong Tsai, Hsin Chang Huang, Ming Yuan Tsai, Yong Diao, Wei Hsuan Hung

Graduate Institute of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold nanoparticles. Furthermore, the nanoparticles were subjected to lateral flow assays using Protein A, and the results revealed that they outperformed conventional spherical gold nanoparticles in terms of color development. This improvement can be attributed to the distinct core/shell structures of our nanoparticles. Further evaluation revealed that these nanoparticles could facilitate the detection of Clostridium difficile Toxin B visually at an extremely low concentration (1 ng/mL) without the requirement for advanced instrumentation. This substantial improvement in sensitivity can be attributed to the meticulous design and nanoscale engineering of the structure of the nanoparticles.

Original language	English
Pages (from-to)	24593-24600
Number of pages	8
Journal	ACS Omega
Volume	9
Issue number	23
DOIs	https://doi.org/10.1021/acsomega.4c00722
State	Published - 11 Jun 2024

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title = "Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile",

abstract = "This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold nanoparticles. Furthermore, the nanoparticles were subjected to lateral flow assays using Protein A, and the results revealed that they outperformed conventional spherical gold nanoparticles in terms of color development. This improvement can be attributed to the distinct core/shell structures of our nanoparticles. Further evaluation revealed that these nanoparticles could facilitate the detection of Clostridium difficile Toxin B visually at an extremely low concentration (1 ng/mL) without the requirement for advanced instrumentation. This substantial improvement in sensitivity can be attributed to the meticulous design and nanoscale engineering of the structure of the nanoparticles.",

author = "Lu, {Ying Tsang} and Zeng, {Yu Xlang} and Tsai, {Wu Xiong} and Huang, {Hsin Chang} and Tsai, {Ming Yuan} and Yong Diao and Hung, {Wei Hsuan}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Published by American Chemical Society.",

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T1 - Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile

AU - Lu, Ying Tsang

AU - Zeng, Yu Xlang

AU - Tsai, Wu Xiong

AU - Huang, Hsin Chang

AU - Tsai, Ming Yuan

AU - Diao, Yong

AU - Hung, Wei Hsuan

PY - 2024/6/11

Y1 - 2024/6/11

N2 - This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold nanoparticles. Furthermore, the nanoparticles were subjected to lateral flow assays using Protein A, and the results revealed that they outperformed conventional spherical gold nanoparticles in terms of color development. This improvement can be attributed to the distinct core/shell structures of our nanoparticles. Further evaluation revealed that these nanoparticles could facilitate the detection of Clostridium difficile Toxin B visually at an extremely low concentration (1 ng/mL) without the requirement for advanced instrumentation. This substantial improvement in sensitivity can be attributed to the meticulous design and nanoscale engineering of the structure of the nanoparticles.

AB - This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold nanoparticles. Furthermore, the nanoparticles were subjected to lateral flow assays using Protein A, and the results revealed that they outperformed conventional spherical gold nanoparticles in terms of color development. This improvement can be attributed to the distinct core/shell structures of our nanoparticles. Further evaluation revealed that these nanoparticles could facilitate the detection of Clostridium difficile Toxin B visually at an extremely low concentration (1 ng/mL) without the requirement for advanced instrumentation. This substantial improvement in sensitivity can be attributed to the meticulous design and nanoscale engineering of the structure of the nanoparticles.

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U2 - 10.1021/acsomega.4c00722

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M3 - 期刊論文

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SN - 2470-1343

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SP - 24593

EP - 24600

JO - ACS Omega

JF - ACS Omega

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Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile

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