Studies on a novel safety-catch linker cleaved by Pummerer rearrangement

Chih Ho Tai; Hsiao Ching Wu; Wen Ren Li

doi:10.1021/ol049120s

Studies on a novel safety-catch linker cleaved by Pummerer rearrangement

Chih Ho Tai, Hsiao Ching Wu, Wen Ren Li

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

(Equation Presented) We describe the use of a sulfide linkage as a safety-catch linker. This linker is significantly stable to acidic as well as basic conditions and allows transformations to be carried out on solid supports. Moreover, its cleavage is facile by applying Pummerer rearrangement after transforming it to sulfoxide.

Original language	English
Pages (from-to)	2905-2908
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	17
DOIs	https://doi.org/10.1021/ol049120s
State	Published - 19 Aug 2004

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abstract = "(Equation Presented) We describe the use of a sulfide linkage as a safety-catch linker. This linker is significantly stable to acidic as well as basic conditions and allows transformations to be carried out on solid supports. Moreover, its cleavage is facile by applying Pummerer rearrangement after transforming it to sulfoxide.",

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AB - (Equation Presented) We describe the use of a sulfide linkage as a safety-catch linker. This linker is significantly stable to acidic as well as basic conditions and allows transformations to be carried out on solid supports. Moreover, its cleavage is facile by applying Pummerer rearrangement after transforming it to sulfoxide.

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JO - Organic Letters

JF - Organic Letters

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Studies on a novel safety-catch linker cleaved by Pummerer rearrangement

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