Spherical crystallization for lean solid-dosage manufacturing (Part II)

Tu Lee, Yan Chan Su, Hung Ju Hou, Hsiang Yu Hsieh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In Part 1 of this article, which appeared in the March 2010 issue of Pharmaceutical Technology, the authors described their approach for constructtiring form spaces for carbamazepine, Cimetidine, and phenylbutazone by initial solvent screening of 19 common organic solvents to evaluate the feasibility of spherical crystallization. In Part Il of this article, the authors discuss their results, which showed that select ternary solvant combinations generated spherical agglomerates in relatively high yields with high friability indices and low angles of repose.

Original languageEnglish
Pages (from-to)88-111
Number of pages24
JournalPharmaceutical Technology
Issue number4
StatePublished - 2010


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