Abstract
Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a fingerprint for solute identification. The total "form space" for acetaminophen and racemic (±)-ibuprofen were calculated to be 222 and 257, respectively. Various crystal habits and sizes for ibuprofen and acetaminophen were observed.
| Original language | English |
|---|---|
| Pages (from-to) | 72-92 |
| Number of pages | 21 |
| Journal | Pharmaceutical Technology |
| Volume | 30 |
| Issue number | 10 |
| State | Published - Oct 2006 |
Keywords
- Active ingredients
- Material characterization
- Scale-up