Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and ibuprofen: By initial solvent screening

Tu Lee, Chung Shin Kuo, Yino Hsiu Chen

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a fingerprint for solute identification. The total "form space" for acetaminophen and racemic (±)-ibuprofen were calculated to be 222 and 257, respectively. Various crystal habits and sizes for ibuprofen and acetaminophen were observed.

Original languageEnglish
Pages (from-to)72-92
Number of pages21
JournalPharmaceutical Technology
Volume30
Issue number10
StatePublished - Oct 2006

Keywords

  • Active ingredients
  • Material characterization
  • Scale-up

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