Solid-phase synthesis of isoquinolinones using Bischler-Napieralski cyclization

Meei Shiou Chern, Wen Ren Li

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A traceless solid-phase synthetic approach to isoquinolinones is described here. This approach allows introducing both electron-donating as well as electron-withdrawing moieties on the benzene nuclei of isoquinolinones with high yields and purities. Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen.

Original languageEnglish
Pages (from-to)8323-8326
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number45
DOIs
StatePublished - 1 Nov 2004

Keywords

  • Bischler-Napieralski cyclization
  • Isoquinolinones
  • Solid-phase synthesis

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