Simultaneous identifications of the minimum effective dose in each of several groups

Show Li Jan, Yuh Ing Chen, Gwowen Shieh

Research output: Contribution to journalArticlepeer-review


One primary goal in dose-response studies for drug development is to identify the minimum effective dose (MED) which is the lowest dose level with an effect that exceeds that of the zero dose control. In this paper, we consider step-down closed testing procedures on the basis of pairwise and Helmert contrasts suggested by Tamhane et al. [Tamhane, A.C., Hochberg, Y., and Dunnett, C.W., 1996, Multiple test procedures for dose finding. Biometrics, 52, 21-37.] for the situation where one wishes to make all such MED identifications simultaneously in each of several groups. An example is given to illustrate the proposed tests. The Monte Carlo studies are further implemented to compare the relative error rate and power performances of the proposed tests.

Original languageEnglish
Pages (from-to)149-161
Number of pages13
JournalJournal of Statistical Computation and Simulation
Issue number2
StatePublished - 1 Feb 2007


  • Dose-response study
  • Helmert contrasts
  • Pairwise contrasts
  • Simultaneous inference
  • Step-down closed test


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