TY - JOUR
T1 - Simultaneous identifications of the minimum effective dose in each of several groups
AU - Jan, Show Li
AU - Chen, Yuh Ing
AU - Shieh, Gwowen
N1 - Funding Information:
The authors wish to thank the associate editor and a referee for their suggestions for improving the clarity of the exposition. The research of the first author was partially supported by National Science Council Grant NSC-89-2118-M-033-002.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - One primary goal in dose-response studies for drug development is to identify the minimum effective dose (MED) which is the lowest dose level with an effect that exceeds that of the zero dose control. In this paper, we consider step-down closed testing procedures on the basis of pairwise and Helmert contrasts suggested by Tamhane et al. [Tamhane, A.C., Hochberg, Y., and Dunnett, C.W., 1996, Multiple test procedures for dose finding. Biometrics, 52, 21-37.] for the situation where one wishes to make all such MED identifications simultaneously in each of several groups. An example is given to illustrate the proposed tests. The Monte Carlo studies are further implemented to compare the relative error rate and power performances of the proposed tests.
AB - One primary goal in dose-response studies for drug development is to identify the minimum effective dose (MED) which is the lowest dose level with an effect that exceeds that of the zero dose control. In this paper, we consider step-down closed testing procedures on the basis of pairwise and Helmert contrasts suggested by Tamhane et al. [Tamhane, A.C., Hochberg, Y., and Dunnett, C.W., 1996, Multiple test procedures for dose finding. Biometrics, 52, 21-37.] for the situation where one wishes to make all such MED identifications simultaneously in each of several groups. An example is given to illustrate the proposed tests. The Monte Carlo studies are further implemented to compare the relative error rate and power performances of the proposed tests.
KW - Dose-response study
KW - Helmert contrasts
KW - Pairwise contrasts
KW - Simultaneous inference
KW - Step-down closed test
UR - http://www.scopus.com/inward/record.url?scp=33751567904&partnerID=8YFLogxK
U2 - 10.1080/10629360600565038
DO - 10.1080/10629360600565038
M3 - 期刊論文
AN - SCOPUS:33751567904
SN - 0094-9655
VL - 77
SP - 149
EP - 161
JO - Journal of Statistical Computation and Simulation
JF - Journal of Statistical Computation and Simulation
IS - 2
ER -