This paper presents the simulation of an autofocus lens design with large depth of field for a cell phone camera. The object distance of the lens is from infinity to 9.754 mm. When the object distance is from infinity to 550 mm, the value of the modulation transfer function (MTF) is greater than 0.6 for the spatial frequency of 114 lp/mm, the optical distortion is less than 1.5%, and the relative illumination is greater than 67%. When the object distance is from 325 to 9.754 mm, the MTF values is greater than 0.4 for close-up shooting. The optical distortion is less than 1.454%, and the relative illumination is greater than 68.8%.