Simulated body-fluid tests and electrochemical investigations on biocompatibility of metallic glasses

C. H. Lin; C. H. Huang; J. F. Chuang; H. C. Lee; M. C. Liu; X. H. Du; J. C. Huang; J. S.C. Jang; C. H. Chen

doi:10.1016/j.msec.2012.07.043

Simulated body-fluid tests and electrochemical investigations on biocompatibility of metallic glasses

C. H. Lin, C. H. Huang, J. F. Chuang, H. C. Lee, M. C. Liu, X. H. Du, J. C. Huang, J. S.C. Jang, C. H. Chen

Graduate Institute of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This paper presents the in-vitro and electrochemical investigations of four metallic glasses (MGs) for finding potential MG-based bio-materials. The simulation body-fluid Hanks solution is utilized for testing the corrosion resistance of MGs, and microorganisms of Escherichia coli are used in testing the bio-toxicity. In addition, a simple cyclic voltammetry method is used for rapid verification of the potential electrochemical responses. It is found that the Zr-based MG can sustain in the body-fluid, exhibiting the best corrosion resistance and electrochemical stability. The microbiologic test shows that E. coli can grow on the surface of the Zr-based metallic glass, confirming the low cell toxicity of this Zr-based MG.

Original language	English
Pages (from-to)	2578-2582
Number of pages	5
Journal	Materials Science and Engineering C
Volume	32
Issue number	8
DOIs	https://doi.org/10.1016/j.msec.2012.07.043
State	Published - 1 Dec 2012

Keywords

Bio-toxicity
Corrosion resistance
Electrochemical stability
Metallic glasses
Simulation body-fluid

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10.1016/j.msec.2012.07.043

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title = "Simulated body-fluid tests and electrochemical investigations on biocompatibility of metallic glasses",

abstract = "This paper presents the in-vitro and electrochemical investigations of four metallic glasses (MGs) for finding potential MG-based bio-materials. The simulation body-fluid Hanks solution is utilized for testing the corrosion resistance of MGs, and microorganisms of Escherichia coli are used in testing the bio-toxicity. In addition, a simple cyclic voltammetry method is used for rapid verification of the potential electrochemical responses. It is found that the Zr-based MG can sustain in the body-fluid, exhibiting the best corrosion resistance and electrochemical stability. The microbiologic test shows that E. coli can grow on the surface of the Zr-based metallic glass, confirming the low cell toxicity of this Zr-based MG.",

keywords = "Bio-toxicity, Corrosion resistance, Electrochemical stability, Metallic glasses, Simulation body-fluid",

author = "Lin, {C. H.} and Huang, {C. H.} and Chuang, {J. F.} and Lee, {H. C.} and Liu, {M. C.} and Du, {X. H.} and Huang, {J. C.} and Jang, {J. S.C.} and Chen, {C. H.}",

note = "Funding Information: The financial supports from the National Science Council under the National Nano Project NSC 100-2120-M-110-004 , and the NSYSU potential research group project are gratefully acknowledged.",

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doi = "10.1016/j.msec.2012.07.043",

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T1 - Simulated body-fluid tests and electrochemical investigations on biocompatibility of metallic glasses

AU - Lin, C. H.

AU - Huang, C. H.

AU - Chuang, J. F.

AU - Lee, H. C.

AU - Liu, M. C.

AU - Du, X. H.

AU - Huang, J. C.

AU - Jang, J. S.C.

AU - Chen, C. H.

N1 - Funding Information: The financial supports from the National Science Council under the National Nano Project NSC 100-2120-M-110-004 , and the NSYSU potential research group project are gratefully acknowledged.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - This paper presents the in-vitro and electrochemical investigations of four metallic glasses (MGs) for finding potential MG-based bio-materials. The simulation body-fluid Hanks solution is utilized for testing the corrosion resistance of MGs, and microorganisms of Escherichia coli are used in testing the bio-toxicity. In addition, a simple cyclic voltammetry method is used for rapid verification of the potential electrochemical responses. It is found that the Zr-based MG can sustain in the body-fluid, exhibiting the best corrosion resistance and electrochemical stability. The microbiologic test shows that E. coli can grow on the surface of the Zr-based metallic glass, confirming the low cell toxicity of this Zr-based MG.

AB - This paper presents the in-vitro and electrochemical investigations of four metallic glasses (MGs) for finding potential MG-based bio-materials. The simulation body-fluid Hanks solution is utilized for testing the corrosion resistance of MGs, and microorganisms of Escherichia coli are used in testing the bio-toxicity. In addition, a simple cyclic voltammetry method is used for rapid verification of the potential electrochemical responses. It is found that the Zr-based MG can sustain in the body-fluid, exhibiting the best corrosion resistance and electrochemical stability. The microbiologic test shows that E. coli can grow on the surface of the Zr-based metallic glass, confirming the low cell toxicity of this Zr-based MG.

KW - Bio-toxicity

KW - Corrosion resistance

KW - Electrochemical stability

KW - Metallic glasses

KW - Simulation body-fluid

UR - http://www.scopus.com/inward/record.url?scp=84866033850&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2012.07.043

DO - 10.1016/j.msec.2012.07.043

M3 - 期刊論文

AN - SCOPUS:84866033850

SN - 0928-4931

VL - 32

SP - 2578

EP - 2582

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

IS - 8

ER -

Simulated body-fluid tests and electrochemical investigations on biocompatibility of metallic glasses

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Keywords

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